| CASE REPORT |
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| Year : 2018 | Volume
: 1
| Issue : 2 | Page : 89-93 |
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Clinical pearls in pediatric anesthetic considerations for peripheral blood stem cell transplant and lacunae in our current knowledge
Shagun B Shah1, Ajay K Bhargava1, Sangeeta Bhagat1, Dinesh Bhurani2, Narendra Agrawal2
1 Department of Anaesthesiology Rajiv Gandhi Cancer Institute and Research Centre, Rohini, New Delhi, India
2 Department of Hemato-Oncology and Bone Marrow Transplant, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, New Delhi, India
Correspondence Address:
Shagun B Shah
H. No: 174–175, Ground Floor, Pocket 17, Sector 24, Rohini, New Delhi 110085
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/JCO.JCO_20_18
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Clinical introduction of peripheral blood stem cell transplant (PBSCT) has replaced bone marrow as a stem cell source in 99% autologous and 75% allogeneic transplantation cases. Incompliant pediatric donors require general anesthesia for PBSCT. Whether the CD34-positive (CD34+) stem cell yield from PBSC donor is affected by age, weight, and sex of donor and type/duration of anesthesia is not very clear from the current literature. These factors may have significant clinical implications as is evident from the poor yield (0.11 million/kg CD34+ cells) on the second day of stem cell harvest from our 2-year-old donor. |
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