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Year : 2018  |  Volume : 1  |  Issue : 2  |  Page : 89-93

Clinical pearls in pediatric anesthetic considerations for peripheral blood stem cell transplant and lacunae in our current knowledge

1 Department of Anaesthesiology Rajiv Gandhi Cancer Institute and Research Centre, Rohini, New Delhi, India
2 Department of Hemato-Oncology and Bone Marrow Transplant, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, New Delhi, India

Correspondence Address:
Shagun B Shah
H. No: 174175, Ground Floor, Pocket 17, Sector 24, Rohini, New Delhi 110085
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JCO.JCO_20_18

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Clinical introduction of peripheral blood stem cell transplant (PBSCT) has replaced bone marrow as a stem cell source in 99% autologous and 75% allogeneic transplantation cases. Incompliant pediatric donors require general anesthesia for PBSCT. Whether the CD34-positive (CD34+) stem cell yield from PBSC donor is affected by age, weight, and sex of donor and type/duration of anesthesia is not very clear from the current literature. These factors may have significant clinical implications as is evident from the poor yield (0.11 million/kg CD34+ cells) on the second day of stem cell harvest from our 2-year-old donor.

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