| CASE REPORT |
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| Year : 2019 | Volume
: 2
| Issue : 1 | Page : 22-25 |
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Pseudoangiomatous stromal hyperplasia presenting as an enlarging breast mass: A case report
Mala M Sharma1, Ajit Nambiar2, Janaki P Dharmarajan3
1 Department of General Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala, India
2 Department of Pathology, Amrita Institute of Medical Sciences, Kochi, Kerala, India
3 Department of Radiology, Amrita Institute of Medical Sciences, Kochi, Kerala, India
Correspondence Address:
Dr. Mala M Sharma
Department of General Surgery, Amrita Institute of Medical Sciences, Ponekkara PO, Edapally, Kochi, Kerala
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/JCO.JCO_25_18
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Pseudoangiomatous stromal hyperplasia (PASH) is an occasional histological finding in the breast tissue, which rarely presents as a clinical mass. We here report a case of progressively increasing breast lump that had radiological ambiguous findings but on excision proved to be PASH on histology and immunohistochemistry (IHC). On microscopy, PASH has to be distinguished from low-grade vascular tumors as stromal spaces in it mimic the endothelium-lined vascular spaces. In view of nonspecific radiological picture, histopathological confirmation by core needle or excision is mandatory. It may coexist with in situ or invasive breast malignancies also. IHC with stromal and vascular markers is the key to diagnosis of PASH; also these tumors show positivity with progesterone markers pointing to endocrine stimulation as a possible etiology. In asymptomatic PASH, expectant management is indicated; however, in symptomatic and enlarging masses, surgical treatment should be preferred. |
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