| CASE REPORT |
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| Year : 2019 | Volume
: 2
| Issue : 1 | Page : 29-32 |
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Radiotherapy as a primary treatment modality for squamous cell carcinoma of tongue in a case of xeroderma pigmentosum
Sakina Mankada, Ankita Parikh, Parag Roy, Amit Kichloo, Ubrangala Suryanarayana
Department of radiation oncology, Gujarat cancer research institute and BJMC, Ahmedabad, India
Correspondence Address:
Dr. Sakina Mankada
A2 Amardeep Apartments, Civil Hospital Road, Ahmedabad, Gujarat
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/JCO.JCO_4_19
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Radiation therapy (RT) represents a important modality for treatment of malignancies in patients of xeroderma pigmentosa (XP). There are only few reports of radiation being primary treatment and thus we report a case of twelve year old female with XP presented with squamous cell carcinoma of tongue and lower lip treated with radiation at our institute. DNA damage by radiation is repaired by base excision repair, non homologous end joining and homologous combination in contrast to XP in which defect lies with nucleotide excision repair genes and therefore clinical and cellular response to RT is similar in XP as seen with other patients. |
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