• Users Online: 62
  • Print this page
  • Email this page
REVIEW ARTICLE
Year : 2021  |  Volume : 4  |  Issue : 1  |  Page : 35-40

Prohibitin gene regulation in cancer and its possible therapeutic potential


1 Xcode Life Sciences, Chennai, Tamil Nadu, India
2 Department of Biosciences, Jamia Millia Islamia, New Delhi, India
3 Department of Laboratory Medicine, Albaha University, Al Bahah, Saudi Arabia
4 Department of Obstetrics and Gynaecology, MAMC, New Delhi, India
5 School of Biological Science, Apeejay Stya University, Gurugram, Haryana, India

Correspondence Address:
Farah Parveen
Department of Biosciences, Jamia Millia Islamia, New Delhi.
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jco.jco_10_21

Get Permissions

Prohibitin (PHB), an evolutionary conserved gene, is mapped at the chromosomal location 17q21–q22 and is present with two isoforms, namely, PHB1 and PHB2. Both of these isoforms have their individual roles in tumor suppression and cell proliferation. The presence of these isoforms is not restricted to single cellular organelle but can be located in the nucleus, mitochondria, and cytosol. Importantly, loss of heterozygosity in the prohibitin gene has been noted in a significant number of different cancer types. Along with this, there are other mutations that contribute to tumorigenesis and cancer cell proliferation. Sporadic breast cancer, lung cancer, and prostate cancer are a few examples in which regulation of PHB plays a major role. PHB has shown to be both up-regulated and down-regulated depending on the type of cancer or disease. PHB acts as the biomarker for several types of cancers and is also seen as a potential therapeutic target. Along with cancer, PHB has also been seen to play an important role in other diseases such as neurological diseases, cardiac diseases, and renal diseases. The link between PHB and a plethora of diseases opens a new window in which PHB can be actually targeted in treatment as well as disease management. Here, we review the regulation of PHB in different types of cancers along with its significant interaction in other disorders.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed380    
    Printed12    
    Emailed0    
    PDF Downloaded51    
    Comments [Add]    

Recommend this journal