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Year : 2021  |  Volume : 4  |  Issue : 1  |  Page : 41-48

Esophageal cancer: Treatment challenges and controversies

Radiation Oncology Department, Shri Ram Murti Institute of Medical Sciences, Bareilly, Uttar Pradesh, India

Correspondence Address:
Dr. Piyush Kumar
Shri Ram Murti Institute of Medical Sciences, Bareilly, Uttar Pradesh.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jco.jco_13_21

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The poor outcomes of esophageal malignancies in terms of local control and survival rates have perplexed radiation oncologists since long time. Chemoradiation has been recognized as a key definitive treatment modality with outcomes comparable to that of surgery. It offers a potential radical treatment option to patients unfit for surgery with the advantage of organ preservation. However, a clear consensus in terms of indications, dose schedules, and techniques of radiation is lacking. In pre- and post-operative settings, lower dose schedules of radiation are recommended. Some evidences suggest that patients receiving radical dose of radiation may derive survival benefit from increased doses. Low-quality emerging evidence suggests promising outcomes with brachytherapy but it needs to be testified further. A detailed review of the existing literature might help to address the controversies in clinical practice.

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