author = {Talapatra, Kaustav. and Karmakar, Shreyasee. and Gupte, Ajinkya. and Srivastava, Amrita.}, title = {{Emergence of SBRT in borderline resectable pancreatic cancer: Is it the way forward?}}, journal ={Journal of Current Oncology}, volume ={4}, number ={2}, pages = {121-126}, doi = {10.4103/jco.jco_22_21}, year = {2021}, abstract ={Pancreatic cancers are aggressive cancers with poor survival outcomes and few effective treatment modalities. The previously used protracted chemo-radiotherapy (CTRT) regimens have not had encouraging results. Stereotactic body radiotherapy (SBRT) has shown encouraging results in the treatment paradigm of borderline resectable pancreatic cancers. Though body of level I evidence is weak currently, studies have shown better resectability with negative margins with neoadjuvant SBRT. Precise contouring, good image guidance, strict quality assurance, and multi-disciplinary spatial co-operation are crucial for its success. High biologically effective dose, smaller margins, short duration of treatment, and strategic sequencing are the key to better outcomes.}, URL ={http://www.https://journalofcurrentoncology.org//article.asp?issn=2589-8892;year=2021;volume=4;issue=2;spage=121;epage=126;aulast=Talapatra;t=6}, eprint ={http://www.https://journalofcurrentoncology.org//article.asp?issn=2589-8892;year=2021;volume=4;issue=2;spage=121;epage=126;aulast=Talapatra;t=6} }